Single-nucleus transcriptomics of epicardial adipose tissue from females reveals exercise control of innate and adaptive immune cells.
Irshad AhmadShreyan GuptaPatricia FaulknerDestiny A MullensMicah ThomasSharanee P SythaIvan V IvanovJames J CaiCristine L HeapsAnnie E Newell-FugatePublished in: bioRxiv : the preprint server for biology (2023)
Coronary artery disease (CAD) is a leading cause of death in women. However, the role of epicardial adipose tissue (EAT) in the development of CAD in females and how exercise, which is recommended to slow CAD progression, impacts EAT are unknown. The effect of aerobic exercise on gene expression in EAT was investigated with RNA-sequencing, revealing significant alterations in fatty acid processing and immunoregulatory processes. This study provides valuable insights into the molecular and cellular changes induced in EAT by exercise in the context of chronic ischemic heart disease in females. These findings bolster current understanding of the impact of aerobic exercise on cardiac health in females and provide a foundation for future research in the field of exercise science.
Keyphrases
- coronary artery disease
- adipose tissue
- high intensity
- gene expression
- physical activity
- public health
- resistance training
- single cell
- insulin resistance
- fatty acid
- healthcare
- percutaneous coronary intervention
- immune response
- coronary artery bypass grafting
- dna methylation
- cardiovascular events
- high fat diet
- mental health
- polycystic ovary syndrome
- heart failure
- mass spectrometry
- type diabetes
- health information
- aortic valve
- oxidative stress
- skeletal muscle
- current status
- risk assessment
- pregnancy outcomes
- transcatheter aortic valve replacement
- aortic stenosis