Neutrophil-driven and interleukin-36γ-associated ocular surface inflammation in chronic Stevens-Johnson syndrome.

Madhuri Amulya KoduriTejaswini PingaliDeeksha PrasadVijay SinghSwati SinghSwapna S ShanbhagSayan BasuVivek Singh

Published in: Allergy (2024)

Our observations indicate a clear correlation between eyelid margin keratinization and the expression of IL-36γ, potentially mediated by neutrophils recruited via IL-8. Future experimental studies are needed to test the role of therapies targeting IL-8 and/or IL-36γ in reducing eyelid margin keratinization and its associated ocular complications in SJS/TEN.

Keyphrases

oxidative stress
poor prognosis
risk factors
case report
binding protein
cancer therapy
optic nerve