Prospective investigation of applicability and the prognostic significance of bone marrow involvement in patients with neuroblastoma detected by quantitative reverse transcription PCR.

Alexander E Druy Egor V Shorikov Grigory A Tsaur Alexander M Popov Artem N ZaychikovSergey N TuponogovLeonid I Saveliev Godelieve A M Tytgat Larisa G Fechina

Published in: Pediatric blood & cancer (2018)

PHOX2B and TH are the most optimal markers for detection of BM involvement, allowing identification of high-risk patients. Predominance of PHOX2B expression over TH has a strong adverse prognostic impact.

Keyphrases

bone marrow
end stage renal disease
ejection fraction
poor prognosis
mesenchymal stem cells
prognostic factors
peritoneal dialysis
high resolution
mass spectrometry
loop mediated isothermal amplification
patient reported
adverse drug