Traditional Chinese medicine Biqi capsule compared with leflunomide in combination with methotrexate in patients with rheumatoid arthritis: a randomized controlled trial.

Zhang WangJiaqi WuDongyun LiXuan TangYue ZhaoXiao CaiXianghong ChenXiumin ChenQingchun HuangRun-Yue Huang

Published in: Chinese medicine (2020)

Our study suggests that Biqi capsule can be a promising alternative option in combination with MTX for RA treatment, and demonstrates the capability of using metabolomics to interrogate mechanism of action for traditional Chinese medicine.Trial registration This trial is registered with ChiCTR, No. ChiCTR-IPR-16009029. Registered August 15, 2016. http://www.chictr.org.cn/showprojen.aspx?proj=15034.

Keyphrases

phase iii
study protocol
phase ii
clinical trial
mass spectrometry
rheumatoid arthritis
high dose
open label
randomized controlled trial
lymph node metastasis
low dose
combination therapy
interstitial lung disease
systemic sclerosis