Multispecific Targeting with Synthetic Ankyrin Repeat Motif Chimeric Antigen Receptors.
Ashwini BalakrishnanAnusha RajanAlexander I SalterPaula L KosasihQian WuJenna VoutsinasMichael C JensenAndreas PlückthunStanley R RiddellPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
DARPins can serve as high-affinity recognition motifs for CAR design, and their robust architecture enables linking of multiple binders against different antigens to achieve functional synergy and reduce antigen escape.