Andreas Plückthun

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 118

Top Venues

Nature communications

Proceedings of the National Academy of Sciences of the United States of America

PLoS pathogens

ACS chemical neuroscience

University of Zurich

University of California at San Diego (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Zurich

Switzerland

Professor :: Biochemistry

Gene Center, Max-Planck Institute for Biochemistry

Germany

Group Leader :: Gene Center

Gene Center LMU c/o Max-Planck-Inst for Biochemistry

Germany

Group Leader :: Gene Center

Education History

University of California at San Diego

United States

PHD :: Chemistry

Publications

Alaa Abdul-Ridha, Lazarus A de Zhang, Ashenafi Haileyesus Betrie, Mattia Deluigi, Tasneem M Vaid, Alice Whitehead, Yifan Zhang, Ben Davis, Richard Harris, Heather Simmonite, Roderick E Hubbard, Paul R Gooley, Andreas Plückthun, Ross A D Bathgate, David K Chalmers, Daniel J Scott
Identification of a Novel Subtype-Selective α 1B -Adrenoceptor Antagonist. ACS chemical neuroscience 15 (3) (2024)
Zhenling Cui, Cagla Ergun Ayva, Yi Jin Liew, Zhong Guo, Roxane Mutschler, Birgit Dreier, Maria M Fiorito, Patricia Walden, Christopher B Howard, Fernanda Ely, Andreas Plückthun, Carel Pretorius, Jacobus Pj Ungerer, Ashley M Buckle, Kirill Alexandrov
mRNA Display Pipeline for Protein Biosensor Construction. ACS sensors 9 (6) (2024)
Julia R Ivanova, Amelie S Benk, Jonas V Schaefer, Birgit Dreier, Leon O Hermann, Andreas Plückthun, Dimitris Missirlis, Joachim Pius Spatz
Designed Ankyrin Repeat Proteins as Actin Labels of Distinct Cytoskeletal Structures in Living Cells. ACS nano 18 (12) (2024)
Yvonne Stark, Faye Menard, Jeliazko R Jeliazkov, Patrick Ernst, Anupama Chembath, Mohammed Ashraf, Anna V Hine, Andreas Plückthun
Modular binder technology by NGS-aided, high-resolution selection in yeast of designed armadillo modules. Proceedings of the National Academy of Sciences of the United States of America 121 (27) (2024)
Alaa Abdul-Ridha, Lazarus A de Zhang, Ashenafi Haileyesus Betrie, Mattia Deluigi, Tasneem M Vaid, Alice Whitehead, Yifan Zhang, Ben Davis, Richard Harris, Heather Simmonite, Roderick E Hubbard, Paul R Gooley, Andreas Plückthun, Ross A D Bathgate, David K Chalmers, Daniel J Scott
Identification of a Novel Subtype-Selective α 1B -Adrenoceptor Antagonist. ACS chemical neuroscience 15 (3) (2024)
Zhenling Cui, Cagla Ergun Ayva, Yi Jin Liew, Zhong Guo, Roxane Mutschler, Birgit Dreier, Maria M Fiorito, Patricia Walden, Christopher B Howard, Fernanda Ely, Andreas Plückthun, Carel Pretorius, Jacobus Pj Ungerer, Ashley M Buckle, Kirill Alexandrov
mRNA Display Pipeline for Protein Biosensor Construction. ACS sensors 9 (6) (2024)
Lars Thalmann, Natalia Martin-Gonzalez, Dominik Brücher, Andreas Plückthun, Pedro J de Pablo, Maarit Suomalainen, Urs F Greber
Gutless Helper-Dependent and First-Generation HAdV5 Vectors Have Similar Mechanical Properties and Common Transduction Mechanisms. Human gene therapy 35 (5-6) (2024)
Zhenling Cui, Cagla Ergun Ayva, Yi Jin Liew, Zhong Guo, Roxane Mutschler, Birgit Dreier, Maria M Fiorito, Patricia Walden, Christopher B Howard, Fernanda Ely, Andreas Plückthun, Carel Pretorius, Jacobus Pj Ungerer, Ashley M Buckle, Kirill Alexandrov
mRNA Display Pipeline for Protein Biosensor Construction. ACS sensors (2024)
Shelby A Auger, Sneha Venkatachalapathy, Kiall Francis G Suazo, Yiao Wang, Alexander W Sarkis, Kaitlyn Bernhagen, Katarzyna Justyna, Jonas V Schaefer, James W Wollack, Andreas Plückthun, Ling Li, Mark D Distefano
Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene-Tetrazine Click Chemistry. Bioconjugate chemistry (2024)
Julia R Ivanova, Amelie S Benk, Jonas V Schaefer, Birgit Dreier, Leon O Hermann, Andreas Plückthun, Dimitris Missirlis, Joachim Pius Spatz
Designed Ankyrin Repeat Proteins as Actin Labels of Distinct Cytoskeletal Structures in Living Cells. ACS nano 18 (12) (2024)
Yvonne Stark, Faye Menard, Jeliazko R Jeliazkov, Patrick Ernst, Anupama Chembath, Mohammed Ashraf, Anna V Hine, Andreas Plückthun
Modular binder technology by NGS-aided, high-resolution selection in yeast of designed armadillo modules. Proceedings of the National Academy of Sciences of the United States of America 121 (27) (2024)
Shelby A Auger, Sneha Venkatachalapathy, Kiall Francis G Suazo, Yiao Wang, Alexander W Sarkis, Kaitlyn Bernhagen, Katarzyna Justyna, Jonas V Schaefer, James W Wollack, Andreas Plückthun, Ling Li, Mark D Distefano
Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene-Tetrazine Click Chemistry. Bioconjugate chemistry (2024)
Shelby A Auger, Sneha Venkatachalapathy, Kiall Francis G Suazo, Yiao Wang, Alexander W Sarkis, Kaitlyn Bernhagen, Katarzyna Justyna, Jonas V Schaefer, James W Wollack, Andreas Plückthun, Ling Li, Mark D Distefano
Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene-Tetrazine Click Chemistry. Bioconjugate chemistry (2024)
Alaa Abdul-Ridha, Lazarus A de Zhang, Ashenafi Haileyesus Betrie, Mattia Deluigi, Tasneem M Vaid, Alice Whitehead, Yifan Zhang, Ben Davis, Richard Harris, Heather Simmonite, Roderick E Hubbard, Paul R Gooley, Andreas Plückthun, Ross A D Bathgate, David K Chalmers, Daniel J Scott
Identification of a Novel Subtype-Selective α 1B -Adrenoceptor Antagonist. ACS chemical neuroscience (2024)
Randa Mahran, Jonas N Kapp, Salla Valtonen, Allison Champagne, Jinying Ning, William Gillette, Andrew G Stephen, Feng Hao, Andreas Plückthun, Harri Härmä, Tatu Pantsar, Kari Kopra
Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96. ACS chemical biology (2024)
Alaa Abdul-Ridha, Lazarus A de Zhang, Ashenafi Haileyesus Betrie, Mattia Deluigi, Tasneem M Vaid, Alice Whitehead, Yifan Zhang, Ben Davis, Richard Harris, Heather Simmonite, Roderick E Hubbard, Paul R Gooley, Andreas Plückthun, Ross A D Bathgate, David K Chalmers, Daniel J Scott
Identification of a Novel Subtype-Selective α 1B -Adrenoceptor Antagonist. ACS chemical neuroscience 15 (3) (2024)
Shelby A Auger, Sneha Venkatachalapathy, Kiall Francis G Suazo, Yiao Wang, Alexander W Sarkis, Kaitlyn Bernhagen, Katarzyna Justyna, Jonas V Schaefer, James W Wollack, Andreas Plückthun, Ling Li, Mark D Distefano
Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene-Tetrazine Click Chemistry. Bioconjugate chemistry 35 (7) (2024)
Julia R Ivanova, Amelie S Benk, Jonas V Schaefer, Birgit Dreier, Leon O Hermann, Andreas Plückthun, Dimitris Missirlis, Joachim Pius Spatz
Designed Ankyrin Repeat Proteins as Actin Labels of Distinct Cytoskeletal Structures in Living Cells. ACS nano 18 (12) (2024)
Alaa Abdul-Ridha, Lazarus A de Zhang, Ashenafi Haileyesus Betrie, Mattia Deluigi, Tasneem M Vaid, Alice Whitehead, Yifan Zhang, Ben Davis, Richard Harris, Heather Simmonite, Roderick E Hubbard, Paul R Gooley, Andreas Plückthun, Ross A D Bathgate, David K Chalmers, Daniel J Scott
Identification of a Novel Subtype-Selective α 1B -Adrenoceptor Antagonist. ACS chemical neuroscience 15 (3) (2024)
Alaa Abdul-Ridha, Lazarus A de Zhang, Ashenafi Haileyesus Betrie, Mattia Deluigi, Tasneem M Vaid, Alice Whitehead, Yifan Zhang, Ben Davis, Richard Harris, Heather Simmonite, Roderick E Hubbard, Paul R Gooley, Andreas Plückthun, Ross A D Bathgate, David K Chalmers, Daniel J Scott
Identification of a Novel Subtype-Selective α 1B -Adrenoceptor Antagonist. ACS chemical neuroscience 15 (3) (2024)
Julia R Ivanova, Amelie S Benk, Jonas V Schaefer, Birgit Dreier, Leon O Hermann, Andreas Plückthun, Dimitris Missirlis, Joachim Pius Spatz
Designed Ankyrin Repeat Proteins as Actin Labels of Distinct Cytoskeletal Structures in Living Cells. ACS nano (2024)
Yvonne Stark, Faye Menard, Jeliazko R Jeliazkov, Patrick Ernst, Anupama Chembath, Mohammed Ashraf, Anna V Hine, Andreas Plückthun
Modular binder technology by NGS-aided, high-resolution selection in yeast of designed armadillo modules. Proceedings of the National Academy of Sciences of the United States of America 121 (27) (2024)
Zhenling Cui, Cagla Ergun Ayva, Yi Jin Liew, Zhong Guo, Roxane Mutschler, Birgit Dreier, Maria M Fiorito, Patricia Walden, Christopher B Howard, Fernanda Ely, Andreas Plückthun, Carel Pretorius, Jacobus Pj Ungerer, Ashley M Buckle, Kirill Alexandrov
mRNA Display Pipeline for Protein Biosensor Construction. ACS sensors 9 (6) (2024)
Julia R Ivanova, Amelie S Benk, Jonas V Schaefer, Birgit Dreier, Leon O Hermann, Andreas Plückthun, Dimitris Missirlis, Joachim Pius Spatz
Designed Ankyrin Repeat Proteins as Actin Labels of Distinct Cytoskeletal Structures in Living Cells. ACS nano 18 (12) (2024)
Alexander Strubel, Philipp Münick, Oliver Hartmann, Apirat Chaikuad, Birgit Dreier, Jonas V Schaefer, Jakob Gebel, Christian Osterburg, Marcel Tuppi, Birgit Schäfer, Viktoria Buck, Mathias Rosenfeldt, Stefan Knapp, Andreas Plückthun, Markus Elmar Diefenbacher, Volker Dötsch
DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma. Cell death & disease 14 (10) (2023)
Stefano Cucuzza, Malgorzata Sitnik, Simon Jurt, Erich Michel, Wenzhao Dai, Thomas Müntener, Patrick Ernst, Daniel Häussinger, Andreas Plückthun, Oliver Zerbe
Unexpected dynamics in femtomolar complexes of binding proteins with peptides. Nature communications 14 (1) (2023)
Christian Baumann, Wan-Chin Chiang, Renato Valsecchi, Simon Jurt, Mattia Deluigi, Matthias Schuster, Karl Johan Rosengren, Andreas Plückthun, Oliver Zerbe
Side-Chain Dynamics of the α 1B -Adrenergic Receptor determined by NMR via Methyl Relaxation. Protein science : a publication of the Protein Society (2023)
Jie Shi, Kristine Hauschulte, Ivan Mikicic, Srijana Maharjan, Valerie Arz, Tina Strauch, Jan B Heidelberger, Jonas V Schaefer, Birgit Dreier, Andreas Plückthun, Petra Beli, Helle D Ulrich, Hans-Peter Wollscheid
Nuclear myosin VI maintains replication fork stability. Nature communications 14 (1) (2023)
Matthias Glögl, Nikolas Friedrich, Gabriele Cerutti, Thomas Lemmin, Young Do Kwon, Jason Gorman, Liridona Maliqi, Peer R E Mittl, Maria Carmen Hesselman, Daniel Schmidt, Jacqueline Weber, Caio Foulkes, Adam S Dingens, Tatsiana Bylund, Adam S Olia, Raffaello Verardi, Thomas Reinberg, Nicolas S Baumann, Peter Rusert, Birgit Dreier, Lawrence Shapiro, Peter D Kwong, Andreas Plückthun, Alexandra Trkola
Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization. Nature structural & molecular biology (2023)
Melanie Gut, Birgit Dreier, Sven Furler, Jens Sobek, Andreas Plückthun, Jason P Holland
Designed ankyrin repeat proteins for detecting prostate-specific antigen expression in vivo . RSC chemical biology 4 (7) (2023)
Marine Blanc, Clara Lettl, Jérémy Guérin, Anaïs Vieille, Sven Furler, Sylvie Briand-Schumacher, Birgit Dreier, Célia Bergé, Andreas Plückthun, Sandrine Vadon-Le Goff, Remi Fronzes, Patricia Rousselle, Wolfgang Fischer, Laurent Terradot
Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system. PLoS pathogens 19 (5) (2023)
Sarah Klinnert, Corinne D Schenkel, Patrick C Freitag, Huldrych F Günthard, Andreas Plückthun, Karin J Metzner
Targeted shock-and-kill HIV-1 gene therapy approach combining CRISPR activation, suicide gene tBid and retargeted adenovirus delivery. Gene therapy (2023)
Marine Blanc, Clara Lettl, Jérémy Guérin, Anaïs Vieille, Sven Furler, Sylvie Briand-Schumacher, Birgit Dreier, Célia Bergé, Andreas Plückthun, Sandrine Vadon-Le Goff, Remi Fronzes, Patricia Rousselle, Wolfgang Fischer, Laurent Terradot
Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system. PLoS pathogens 19 (5) (2023)
Marine Blanc, Clara Lettl, Jérémy Guérin, Anaïs Vieille, Sven Furler, Sylvie Briand-Schumacher, Birgit Dreier, Célia Bergé, Andreas Plückthun, Sandrine Vadon-Le Goff, Remi Fronzes, Patricia Rousselle, Wolfgang Fischer, Laurent Terradot
Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system. PLoS pathogens 19 (5) (2023)
Oneda Leka, Yufan Wu, Giulia Zanetti, Sven Furler, Thomas Reinberg, Joana Marinho, Jonas V Schaefer, Andreas Plückthun, Xiaodan Li, Marco Pirazzini, Richard A Kammerer
A DARPin promotes faster onset of botulinum neurotoxin A1 action. Nature communications 14 (1) (2023)
Marine Blanc, Clara Lettl, Jérémy Guérin, Anaïs Vieille, Sven Furler, Sylvie Briand-Schumacher, Birgit Dreier, Célia Bergé, Andreas Plückthun, Sandrine Vadon-Le Goff, Remi Fronzes, Patricia Rousselle, Wolfgang Fischer, Laurent Terradot
Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system. PLoS pathogens 19 (5) (2023)
Marine Blanc, Clara Lettl, Jérémy Guérin, Anaïs Vieille, Sven Furler, Sylvie Briand-Schumacher, Birgit Dreier, Célia Bergé, Andreas Plückthun, Sandrine Vadon-Le Goff, Remi Fronzes, Patricia Rousselle, Wolfgang Fischer, Laurent Terradot
Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system. PLoS pathogens 19 (5) (2023)
Christoph Klenk, Maria Scrivens, Anina Niederer, Shuying Shi, Loretta Mueller, Elaine Gersz, Maurice Zauderer, Ernest S Smith, Ralf Strohner, Andreas Plückthun
A Vaccinia-based system for directed evolution of GPCRs in mammalian cells. Nature communications 14 (1) (2023)
Marine Blanc, Clara Lettl, Jérémy Guérin, Anaïs Vieille, Sven Furler, Sylvie Briand-Schumacher, Birgit Dreier, Célia Bergé, Andreas Plückthun, Sandrine Vadon-Le Goff, Remi Fronzes, Patricia Rousselle, Wolfgang Fischer, Laurent Terradot
Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system. PLoS pathogens 19 (5) (2023)
Liridona Maliqi, Nikolas Friedrich, Matthias Glögl, Stefan Schmutz, Daniel Schmidt, Peter Rusert, Merle Schanz, Maryam Zaheri, Chloé Pasin, Cyrille Niklaus, Caio Foulkes, Thomas Reinberg, Birgit Dreier, Irene Abela, David Peterhoff, Alexandra Hauser, Roger D Kouyos, Huldrych F Gunthard, Marit J VAN Gils, Rogier W Sanders, Ralf Wagner, Andreas Plückthun, Alexandra Trkola
Assessing immunogenicity barriers of the HIV-1 envelope trimer. NPJ vaccines 8 (1) (2023)
Rajib Schubert, Taegeun Bae, Branko Simic, Sheena N Smith, Seong-Ho Park, Gabriela Nagy-Davidescu, Viviana Gradinaru, Andreas Plückthun, Junho K Hur
CRISPR-clear imaging of melanin-rich B16-derived solid tumors. Communications biology 6 (1) (2023)
Christoph Klenk, Maria Scrivens, Anina Niederer, Shuying Shi, Loretta Mueller, Elaine Gersz, Maurice Zauderer, Ernest S Smith, Ralf Strohner, Andreas Plückthun
A Vaccinia-based system for directed evolution of GPCRs in mammalian cells. Nature communications 14 (1) (2023)
Oneda Leka, Yufan Wu, Giulia Zanetti, Sven Furler, Thomas Reinberg, Joana Marinho, Jonas V Schaefer, Andreas Plückthun, Xiaodan Li, Marco Pirazzini, Richard A Kammerer
A DARPin promotes faster onset of botulinum neurotoxin A1 action. Nature communications 14 (1) (2023)
Oneda Leka, Yufan Wu, Giulia Zanetti, Sven Furler, Thomas Reinberg, Joana Marinho, Jonas V Schaefer, Andreas Plückthun, Xiaodan Li, Marco Pirazzini, Richard A Kammerer
A DARPin promotes faster onset of botulinum neurotoxin A1 action. Nature communications 14 (1) (2023)
Christoph Klenk, Maria Scrivens, Anina Niederer, Shuying Shi, Loretta Mueller, Elaine Gersz, Maurice Zauderer, Ernest S Smith, Ralf Strohner, Andreas Plückthun
A Vaccinia-based system for directed evolution of GPCRs in mammalian cells. Nature communications 14 (1) (2023)
Christoph Klenk, Maria Scrivens, Anina Niederer, Shuying Shi, Loretta Mueller, Elaine Gersz, Maurice Zauderer, Ernest S Smith, Ralf Strohner, Andreas Plückthun
A Vaccinia-based system for directed evolution of GPCRs in mammalian cells. Nature communications 14 (1) (2023)
Yi Zhang, Yiao Wang, Safak Uslu, Sneha Venkatachalapathy, Mohammad Rashidian, Jonas V Schaefer, Andreas Plückthun, Mark D Distefano
Enzymatic Construction of DARPin-Based Targeted Delivery Systems Using Protein Farnesyltransferase and a Capture and Release Strategy. International journal of molecular sciences 23 (19) (2022)
Mattia Deluigi, Lena Morstein, Matthias Schuster, Christoph Klenk, Lisa Merklinger, Riley R Cridge, Lazarus A de Zhang, Alexander Klipp, Santiago Vacca, Tasneem M Vaid, Peer R E Mittl, Pascal Egloff, Stefanie A Eberle, Oliver Zerbe, David K Chalmers, Daniel J Scott, Andreas Plückthun
Crystal structure of the α 1B -adrenergic receptor reveals molecular determinants of selective ligand recognition. Nature communications 13 (1) (2022)
Jendrik Schöppe, Janosch Ehrenmann, Yann Waltenspühl, Andreas Plückthun
Universal platform for the generation of thermostabilized GPCRs that crystallize in LCP. Nature protocols 17 (3) (2022)
Shinya Matsuda, Jonas V Schaefer, Yusuke Mii, Yutaro Hori, Dimitri Bieli, Masanori Taira, Andreas Plückthun, Markus Affolter
Author Correction: Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc. Nature communications 13 (1) (2022)
Tobias Strittmatter, Yidan Wang, Adrian Bertschi, Leo Scheller, Patrick C Freitag, Preetam Guha Ray, Pascal Stuecheli, Jonas V Schaefer, Thomas Reinberg, Dimitrios Tsakiris, Andreas Plückthun, Haifeng Ye, Martin Fussenegger
Programmable DARPin-based receptors for the detection of thrombotic markers. Nature chemical biology 18 (10) (2022)
Cedric Kiss, Flavio M Gall, Birgit Dreier, Michael Adams, Rainer Riedl, Andreas Plückthun, Peer R E Mittl
Structure of a hydrophobic leucinostatin derivative determined by host lattice display. Acta crystallographica. Section D, Structural biology 78 (Pt 12) (2022)
Erich Michel, Stefano Cucuzza, Peer R E Mittl, Oliver Zerbe, Andreas Plückthun
Improved Repeat Protein Stability by Combined Consensus and Computational Protein Design. Biochemistry (2022)
Chao Qi, Pia Lavriha, Ved Mehta, Basavraj Khanppnavar, Inayathulla Mohammed, Yong Li, Michalis Lazaratos, Jonas V Schaefer, Birgit Dreier, Andreas Plückthun, Ana-Nicoleta Bondar, Carmen W Dessauer, Volodymyr M Korkhov
Structural basis of adenylyl cyclase 9 activation. Nature communications 13 (1) (2022)
Sofia S Guimaraes Koch, Robin Thorpe, Nana Kawasaki, Marie-Paule Lefranc, Sarel F Malan, Andrew C R Martin, Gilles Mignot, Andreas Plückthun, Menico Rizzi, Stephanie Shubat, Karin Weisser, Raffaella Balocco
International nonproprietary names for monoclonal antibodies: an evolving nomenclature system. mAbs 14 (1) (2022)
Andrew Raymon Morton Bradbury, Stefan Dübel, Achim Knappik, Andreas Plückthun
Animal- versus in vitro-derived antibodies: avoiding the extremes. mAbs 13 (1) (2022)
Rachael Fay, Imre Törő, Anna-Lena Schinke, Branko Simic, Jonas V Schaefer, Birgit Dreier, Andreas Plückthun, Jason P Holland
Sortase-Mediated Site-Specific Conjugation and 89 Zr-Radiolabeling of Designed Ankyrin Repeat Proteins for PET. Molecular pharmaceutics 19 (10) (2022)
Kari Kopra, Salla Valtonen, Randa Mahran, Jonas N Kapp, Nazia Hassan, William K Gillette, Bryce Dennis, Lianbo Li, Kenneth D Westover, Andreas Plückthun, Harri Härmä
Thermal Shift Assay for Small GTPase Stability Screening: Evaluation and Suitability. International journal of molecular sciences 23 (13) (2022)
Patrick C Freitag, Fabian Brandl, Dominik Brücher, Fabian Weiss, Birgit Dreier, Andreas Plückthun
Modular Adapters Utilizing Binders of Different Molecular Types Expand Cell-Targeting Options for Adenovirus Gene Delivery. Bioconjugate chemistry 33 (9) (2022)
Nicole Kirchhammer, Marcel Philipp Trefny, Marina Natoli, Dominik Brücher, Sheena N Smith, Franziska Werner, Victoria Koch, David Schreiner, Ewelina Magdalena Bartoszek, Mélanie Buchi, Markus Schmid, Daniel Breu, K Patricia Hartmann, Polina Zaytseva, Daniela S Thommen, Heinz Laubli, Jan Philipp Böttcher, Michal A Stanczak, Abhishek S Kashyap, Andreas Plückthun, Alfred Zippelius
NK cells with tissue-resident traits shape response to immunotherapy by inducing adaptive antitumor immunity. Science translational medicine 14 (653) (2022)
Alexander Strubel, Philipp Münick, Apirat Chaikuad, Birgit Dreier, Jonas Schaefer, Jakob Gebel, Christian Osterburg, Marcel Tuppi, Birgit Schäfer, Stefan Knapp, Andreas Plückthun, Volker Dötsch
Designed Ankyrin Repeat Proteins as a tool box for analyzing p63. Cell death and differentiation (2022)
Yann Waltenspühl, Janosch Ehrenmann, Santiago Vacca, Cristian Thom, Ohad Medalia, Andreas Plückthun
Structural basis for the activation and ligand recognition of the human oxytocin receptor. Nature communications 13 (1) (2022)
Ilaria Incaviglia, Andreas Frutiger, Yves Blickenstorfer, Fridolin Treindl, Giulia Ammirati, Ines Lüchtefeld, Birgit Dreier, Andreas Plückthun, János Vörös, Andreas M Reichmuth
An Approach for the Real-Time Quantification of Cytosolic Protein-Protein Interactions in Living Cells. ACS sensors 6 (4) (2021)
Florian Kast, Martin Schwill, Jakob C Stüber, Svende Pfundstein, Gabriela Nagy-Davidescu, Josep M Monné Rodríguez, Frauke Seehusen, Christian P Richter, Annemarie Honegger, Karen Patricia Hartmann, Thomas G Weber, Felix Kroener, Patrick Ernst, Jacob Piehler, Andreas Plückthun
Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action. Nature communications 12 (1) (2021)
Ivan Vulovic, Qing Yao, Young-Jun Park, Alexis Courbet, Andrew S Norris, Florian Busch, Aniruddha Sahasrabuddhe, Hannes Merten, Danny D Sahtoe, George Ueda, Jorge A Fallas, Sara J Weaver, Yang Hsia, Robert A Langan, Andreas Plückthun, Vicki H Wysocki, David Veesler, George J Lu, Julien S Baker
Generation of ordered protein assemblies using rigid three-body fusion. Proceedings of the National Academy of Sciences of the United States of America 118 (23) (2021)
Lukas Becker, Jasleen Singh Badwal, Fabian Brandl, Wouter P R Verdurmen, Andreas Plückthun
Thermodynamic Stability Is a Strong Predictor for the Delivery of DARPins to the Cytosol via Anthrax Toxin. Pharmaceutics 13 (8) (2021)
Jakob C Stüber, Christian P Richter, Junel Sotolongo Bellón, Martin Schwill, Iwo König, Benjamin Schuler, Jacob Piehler, Andreas Plückthun
Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization. Communications biology 4 (1) (2021)
Meng Zhang, Miao Gui, Zi-Fu Wang, Christoph Gorgulla, James J Yu, Hao Wu, Zhen-Yu J Sun, Christoph Klenk, Lisa Merklinger, Lena Morstein, Franz Hagn, Andreas Plückthun, Alan Brown, Mahmoud L Nasr, Gerhard Wagner
Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs. Nature structural & molecular biology 28 (3) (2021)
Yann Waltenspühl, Janosch Ehrenmann, Christoph Klenk, Andreas Plückthun
Engineering of Challenging G Protein-Coupled Receptors for Structure Determination and Biophysical Studies. Molecules (Basel, Switzerland) 26 (5) (2021)
Dominik Brücher, Vojtech Franc, Sheena N Smith, Albert J R Heck, Andreas Plückthun
Malignant tissues produce divergent antibody glycosylation of relevance for cancer gene therapy effectiveness. mAbs 12 (1) (2021)
Stefano Cucuzza, Peter Güntert, Andreas Plückthun, Oliver Zerbe
An automated iterative approach for protein structure refinement using pseudocontact shifts. Journal of biomolecular NMR 75 (8-9) (2021)
Venkatesh P Mysore, Zhi-Wei Zhou, Chiara Ambrogio, Lianbo Li, Jonas N Kapp, Chunya Lu, Qi Wang, Maxwell R Tucker, Jeffrey J Okoro, Gabriela Nagy-Davidescu, Xiao-Chen Bai, Andreas Plückthun, Pasi A Janne, Kenneth D Westover, Yibing Shan, David E Shaw
A structural model of a Ras-Raf signalosome. Nature structural & molecular biology 28 (10) (2021)
Mattia Deluigi, Alexander Klipp, Christoph Klenk, Lisa Merklinger, Stefanie A Eberle, Lena Morstein, Philipp Heine, Peer R E Mittl, Patrick Ernst, Theodore M Kamenecka, Yuanjun He, Santiago Vacca, Pascal Egloff, Annemarie Honegger, Andreas Plückthun
Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Science advances 7 (5) (2021)
Nikolas Friedrich, Emanuel Stiegeler, Matthias Glögl, Thomas Lemmin, Simon Hansen, Claus Kadelka, Yufan Wu, Patrick Ernst, Liridona Maliqi, Caio Foulkes, Mylène Morin, Mustafa Eroglu, Thomas Liechti, Branislav Ivan, Thomas Reinberg, Jonas V Schaefer, Umut Karakus, Stephan Ursprung, Axel Mann, Peter Rusert, Roger D Kouyos, John A Robinson, Huldrych F Gunthard, Andreas Plückthun, Alexandra Trkola
Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization. Nature communications 12 (1) (2021)
Cristian Thom, Janosch Ehrenmann, Santiago Vacca, Yann Waltenspühl, Jendrik Schöppe, Ohad Medalia, Andreas Plückthun
Structures of neurokinin 1 receptor in complex with Gq and Gs proteins reveal substance P binding mode and unique activation features. Science advances 7 (50) (2021)
Shinya Matsuda, Jonas V Schaefer, Yusuke Mii, Yutaro Hori, Dimitri Bieli, Masanori Taira, Andreas Plückthun, Markus Affolter
Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc. Nature communications 12 (1) (2021)
Erin A Stephens, Morgan B Ludwicki, Bunyarit Meksiriporn, Mingji Li, Tianzheng Ye, Connor Monticello, Katherine J Forsythe, Lutz Kummer, Pengbo Zhou, Andreas Plückthun, Matthew P DeLisa
Engineering Single Pan-Specific Ubiquibodies for Targeted Degradation of All Forms of Endogenous ERK Protein Kinase. ACS synthetic biology 10 (9) (2021)
Manuela Bieri, Rodinde Hendrickx, Michael Bauer, Bin Yu, Tania Jetzer, Birgit Dreier, Peer R E Mittl, Jens Sobek, Andreas Plückthun, Urs F Greber, Silvio Hemmi
The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection. PLoS pathogens 17 (12) (2021)
Sheena N Smith, Rajib Schubert, Branko Simic, Dominik Brücher, Markus Schmid, Niels Kirk, Patrick C Freitag, Viviana Gradinaru, Andreas Plückthun
The SHREAD gene therapy platform for paracrine delivery improves tumor localization and intratumoral effects of a clinical antibody. Proceedings of the National Academy of Sciences of the United States of America 118 (21) (2021)
Jan L A Voskuil, Anita E Bandrowski, C Glenn Begley, Andrew Raymon Morton Bradbury, Andrew D Chalmers, Aldrin V Gomes, Travis Hardcastle, Fridtjof Lund-Johansen, Andreas Plückthun, Giovanna Roncador, Alejandra Solache, Michael J Taussig, James S Trimmer, Cecilia Williams, Simon L Goodman
The Antibody Society's antibody validation webinar series. mAbs 12 (1) (2021)
William D Teale, Taras Pasternak, Cristina Dal Bosco, Alexander Dovzhenko, Krystyna Kratzat, Wolfgang Bildl, Manuel Schwörer, Thorsten Falk, Benadetto Ruperti, Jonas V Schaefer, Mojgan Shahriari, Lena Pilgermayer, Xugang Li, Florian Lübben, Andreas Plückthun, Uwe Schulte, Klaus Palme
Flavonol-mediated stabilization of PIN efflux complexes regulates polar auxin transport. The EMBO journal 40 (1) (2020)
Yann Waltenspühl, Jendrik Schöppe, Janosch Ehrenmann, Lutz Kummer, Andreas Plückthun
Crystal structure of the human oxytocin receptor. Science advances 6 (29) (2020)
Antoine Chabloz, Jonas V Schaefer, Ivona Kozieradzki, Shane J F Cronin, Daniel Strebinger, Francesca Macaluso, Jiri Wald, Terence Howard Rabbitts, Andreas Plückthun, Thomas C Marlovits, Josef M Penninger
Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol. Communications biology 3 (1) (2020)
Alison Gray, Andrew Raymon Morton Bradbury, Achim Knappik, Andreas Plückthun, Carl A K Borrebaeck, Stefan Dübel
Animal-free alternatives and the antibody iceberg. Nature biotechnology 38 (11) (2020)
Lukas Becker, Wouter P R Verdurmen, Andreas Plückthun
Reengineering anthrax toxin protective antigen for improved receptor-specific protein delivery. BMC biology 18 (1) (2020)
Inguna Goba, David Goricanec, Dominik Schum, Matthias Hillenbrand, Andreas Plückthun, Franz Hagn
Probing the Conformation States of Neurotensin Receptor 1 Variants by NMR Site-Directed Methyl Labeling. Chembiochem : a European journal of chemical biology 22 (1) (2020)
Kathrin Nowak, Florian Rosenthal, Tobias Karlberg, Mareike Bütepage, Ann-Gerd Thorsell, Birgit Dreier, Jonas Grossmann, Jens Sobek, Ralph Imhof, Bernhard Lüscher, Herwig Schüler, Andreas Plückthun, Deena M Leslie Pedrioli, Michael O Hottiger
Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins. Nature communications 11 (1) (2020)
Patrick Ernst, Franziska Zosel, Christian Reichen, Daniel Nettels, Benjamin Schuler, Andreas Plückthun
Structure-Guided Design of a Peptide Lock for Modular Peptide Binders. ACS chemical biology 15 (2) (2020)
Kirsten Deprey, Lukas Becker, Joshua A Kritzer, Andreas Plückthun
Trapped! A Critical Evaluation of Methods for Measuring Total Cellular Uptake versus Cytosolic Localization. Bioconjugate chemistry 30 (4) (2019)
Jendrik Schöppe, Janosch Ehrenmann, Christoph Klenk, Prakash Rucktooa, Marco Schütz, Andrew S Doré, Andreas Plückthun
Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists. Nature communications 10 (1) (2019)
Ashwini Balakrishnan, Anusha Rajan, Alexander I Salter, Paula L Kosasih, Qian Wu, Jenna Voutsinas, Michael C Jensen, Andreas Plückthun, Stanley R Riddell
Multispecific Targeting with Synthetic Ankyrin Repeat Motif Chimeric Antigen Receptors. Clinical cancer research : an official journal of the American Association for Cancer Research 25 (24) (2019)
P Heine, G Witt, A Gilardi, P Gribbon, L Kummer, Andreas Plückthun
High-Throughput Fluorescence Polarization Assay to Identify Ligands Using Purified G Protein-Coupled Receptor. SLAS discovery : advancing life sciences R & D 24 (9) (2019)
Bunyarit Meksiriporn, Morgan B Ludwicki, Erin A Stephens, Allen Jiang, Hyeon-Cheol Lee, Dujduan Waraho-Zhmayev, Lutz Kummer, Fabian Brandl, Andreas Plückthun, Matthew P DeLisa
A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins. Nature communications 10 (1) (2019)
Martin Schwill, Rastislav Tamaskovic, Aaron S Gajadhar, Florian Kast, Forest M White, Andreas Plückthun
Systemic analysis of tyrosine kinase signaling reveals a common adaptive response program in a HER2-positive breast cancer. Science signaling 12 (565) (2019)
Jakob C Stüber, Florian Kast, Andreas Plückthun
High-Throughput Quantification of Surface Protein Internalization and Degradation. ACS chemical biology 14 (6) (2019)
Abhinav Kumar, Andreas Plückthun
In vivo assembly and large-scale purification of a GPCR - Gα fusion with Gβγ, and characterization of the active complex. PloS one 14 (1) (2019)
Valérie Campanacci, Agathe Urvoas, Soraya Cantos-Fernandes, Magali Aumont-Nicaise, Ana-Andreea Arteni, Christophe Velours, Marie Valerio-Lepiniec, Birgit Dreier, Andreas Plückthun, Antoine Pilon, Christian Poüs, Philippe Minard, Benoît Gigant
Insight into microtubule nucleation from tubulin-capping proteins. Proceedings of the National Academy of Sciences of the United States of America 116 (20) (2019)
Miha Renko, Marc Fiedler, Trevor J Rutherford, Jonas V Schaefer, Andreas Plückthun, Mariann Bienz
Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome. Proceedings of the National Academy of Sciences of the United States of America 116 (42) (2019)
Pablo Emiliano Tomatis, Marco Schütz, Elina Umudumov, Andreas Plückthun
Mutations in sigma 70 transcription factor improves expression of functional eukaryotic membrane proteins in Escherichia coli. Scientific reports 9 (1) (2019)
Janosch Ehrenmann, Jendrik Schöppe, Christoph Klenk, Andreas Plückthun
New views into class B GPCRs from the crystal structure of PTH1R. The FEBS journal 286 (24) (2019)

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Andreas Plückthun