Identifying Human Specific Adverse Outcome Pathways of Per- and Polyfluoroalkyl Substances Using Liver-Chimeric Humanized Mice.

Dakota R RobartsDiego Paine-CabreraManasi KotulkarKaitlyn K VennemanSumedha GunewardenaJ Christopher CortonChristopher LauLander FoquetGreg BialUdayan Apte

Published in: bioRxiv : the preprint server for biology (2023)

These data implicate PFAS in circadian rhythm disruption via inhibition of NR1D1. These studies show that FRG humanized mice are a useful tool for studying the adverse outcome pathways of environmental pollutants on human hepatocytes in situ.

Keyphrases

endothelial cells
induced pluripotent stem cells
high fat diet induced
pluripotent stem cells
monoclonal antibody
heart rate
risk assessment
mesenchymal stem cells
wild type
deep learning
human health