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Modulation of the HIF-1α-NCOA4-FTH1 Signaling Axis Regulating Ferroptosis-induced Hepatic Stellate Cell Senescence to Explore the Anti-hepatic Fibrosis Mechanism of Curcumol.

Yang ZhengLei WangJiaru WangTiejian ZhaoJiahui Wang
Published in: Current medicinal chemistry (2024)
Overall, curcumol induces ferroptosis and cellular senescence by increasing HIF-1α expression and increasing NCOA4 interaction with FTH1, leading to massive deposition of LIP and iron ions, which may be the molecular biological mechanism of its anti-liver fibrosis.
Keyphrases
  • liver fibrosis
  • endothelial cells
  • high glucose
  • cell death
  • dna damage
  • poor prognosis
  • stress induced
  • single cell
  • quantum dots
  • oxidative stress
  • water soluble