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DNA methyltransferase expression is associated with cell proliferation in salivary mucoepidermoid carcinoma.

Douglas Magno GuimaraesFabio deLucas da Silva AlmeidaRogerio de Moraes CastilhoJaques Eduardo NorFabio Daumas Nunes
Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2020)
The expression of DNMT1, DNMT3A, DNMT3B is correlated significantly with the expression of Ki-67 and cyclin D1. The treatment with 5AC reduces DNMT expression and decreases the percentage of cells at the G2/M phase of the cell cycle, while increasing the cells at the G0/G1 phase.
Keyphrases
  • cell cycle
  • poor prognosis
  • cell proliferation
  • dna methylation
  • induced apoptosis
  • cell cycle arrest
  • binding protein
  • cell death
  • signaling pathway
  • combination therapy