Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers.

Midori HonmaShojiro SawadaYoshiyuki UenoKeigo MurakamiTetsuya YamadaJunhong GaoShinjiro KodamaTomohito IzumiKei TakahashiSohei TsukitaKenji UnoJunta ImaiEiji KakazuYasuteru KondoKei MizunoNaoki KawagishiTooru ShimosegawaHideki Katagiri

Published in: International journal of obesity (2005) (2018)

These analyses revealed that selective insulin resistance is present in human NAFLD livers and occurs in its early phases. The effect of insulin, during the IRS step, on gene expressions for lipogenesis and gluconeogenesis are apparently distinct and preferential downregulation of IRS-2 may contribute to selective resistance to the suppressive effects of insulin on gluconeogenesis.

Keyphrases

insulin resistance
type diabetes
endothelial cells
glycemic control
adipose tissue
induced pluripotent stem cells
metabolic syndrome
high fat diet induced
high fat diet
pluripotent stem cells
polycystic ovary syndrome
cell proliferation
copy number
weight loss