Immune Checkpoint Inhibitors and Cardiotoxicity: A Comparative Meta-Analysis of Observational Studies and Randomized Controlled Trials.
Akash SharmaGrace AlexanderJian H ChuArtemis MarkopoulosGilgamish MaloulMuhammad Talha AyubMary J FidlerTochukwu M OkwuosaPublished in: Journal of the American Heart Association (2024)
We demonstrated increased risk of ICI myocarditis, pericardial disease, and myocardial infarction in RCTs but not OSs. Results of this study suggest there are differences between ICI cardiotoxicity risk, possibly suggesting differences in diagnoses and management, in clinical trials versus the OSs.