Toluene-induced leukodystrophy from glue sniffing.
Norlinah Mohamed IbrahimAhmad Shahir MawardiNorzaini Rose ZainShanthi ViswanathanPublished in: Practical neurology (2021)
A 33-year-old man with a history of chronic toluene abuse through glue sniffing, developed tremors, cerebellar signs and cognitive decline. MR scan of the brain showed global cerebral and cerebellar atrophy with symmetrical T2-weighted hypointensities in the basal ganglia, thalami and midbrain. After stopping glue sniffing, his tremors, ataxia of gait, speech and cognition partially improved. Early recognition and intervention of toluene-induced leukodystrophy could prevent ongoing morbidity and premature mortality.
Keyphrases
- cognitive decline
- mild cognitive impairment
- high glucose
- diabetic rats
- drug induced
- randomized controlled trial
- magnetic resonance
- white matter
- computed tomography
- subarachnoid hemorrhage
- cardiovascular events
- type diabetes
- cardiovascular disease
- coronary artery disease
- endothelial cells
- multiple sclerosis
- risk factors
- functional connectivity
- stress induced