EGFR/MEK inhibitor therapy induces a distinct inflammatory hair follicle response that includes a collapse of immune privilege.
David RutkowskiRachel ScholeyJohn S DaviesDerek PyeFiona BlackhallRichard Bruce WarrenFrancisco JimenezChristopher Ernest Maitland GriffithsRalf PausPublished in: The British journal of dermatology (2024)
These data show that EGFRi/MEKi compromise the physiological IP of human scalp HFs and suggest that future clinical management of EGFRi/MEKi-induced folliculitis requires HF IP protection and inhibition of IL-33.
Keyphrases
- endothelial cells
- high glucose
- small cell lung cancer
- diabetic rats
- epidermal growth factor receptor
- oxidative stress
- tyrosine kinase
- electronic health record
- induced pluripotent stem cells
- current status
- pluripotent stem cells
- pi k akt
- drug induced
- machine learning
- cell proliferation
- mesenchymal stem cells
- data analysis
- atrial fibrillation
- deep learning
- smoking cessation