Novel high-affinity EGFRvIII-specific chimeric antigen receptor T cells effectively eliminate human glioblastoma.

Rebecca C Abbott Daniel J VerdonFiona M GraceyHannah E Hughes-ParryMelinda IliopoulosKatherine A WatsonMatthias MulazzaniKylie LuongColleen D'ArcyLucy C SullivanBen R KiefelRyan S Cross Misty R Jenkins

Published in: Clinical & translational immunology (2021)

We present a novel EGFRvIII-specific CAR, with effective antitumor functions both in in vitro and in a xenograft model of human glioblastoma.

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