The impact of different classes of lupus nephritis on maternal and fetal outcomes: a cohort study of 147 pregnancies.
B Costa RodriguesM Ignacchiti LacerdaG R Ramires de JesúsFlávia Cunha Dos SantosN Ramires de JesúsR A LevyE Mendes KlumbPublished in: Lupus (2019)
Systemic lupus erythematosus patients with proliferative nephritis (classes III/IV) have a higher frequency of adverse maternal outcomes. This is probably due to the major impact of proliferative forms of nephritis on women's global heath, which is corroborated by the higher Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index findings, although we cannot exclude the negative influence of disease activity for the maternal adverse events. The findings indicate a need for further lupus nephritis classification beyond the nonspecific term nephritis in the context of lupus pregnancy as the impact on maternal and fetal outcomes varies according to histological class.
Keyphrases
- systemic lupus erythematosus
- disease activity
- pregnancy outcomes
- birth weight
- rheumatoid arthritis
- rheumatoid arthritis patients
- juvenile idiopathic arthritis
- ankylosing spondylitis
- gestational age
- pregnant women
- preterm birth
- primary care
- polycystic ovary syndrome
- oxidative stress
- deep learning
- preterm infants
- weight gain
- adipose tissue
- electronic health record
- weight loss