Analysis of the expression profile of long non-coding RNAs MALAT1 and THRIL in children with immune thrombocytopenia.

Shymaa E AyoubEnas Mamdouh HefzyRehab G Abd El-HmidNaglaa A AhmedAbeer A KhalefaDoaa Y AliMarwa A Ali

Published in: IUBMB life (2020)

Both lncRNAs MALAT1 and THRIL were significantly upregulated in ITP patients in comparison to HCs ( p < .0001 and = .001 respectively). In addition, there was a positive significant correlation between the expression level of both biomarkers among patients (r = 0.745, p < .0001). At cutoff points of 1.17 and 1.27 for lncRNAs MALAT1and THRIL, respectively, both biomarkers had an excellent specificity (100% for both) and fair sensitivity (63.6 and 73.3% for lncRNAs MALAT1and THRIL, respectively). Improvement of biomarkers specificity was obtained by evaluation of the combined expression of both biomarkers. Serum lncRNAs MALAT1 and THRIL could be used as potential biomarkers in differentiating childhood ITP patients and HCs.

Keyphrases

poor prognosis
end stage renal disease
long non coding rna
ejection fraction
newly diagnosed
peritoneal dialysis
prognostic factors
young adults
magnetic resonance
computed tomography
network analysis
transcription factor
genome wide analysis
structural basis