Login / Signup

Calpain: The regulatory point of cardiovascular and cerebrovascular diseases.

Xiaolu ZhangYujia ZhengZiyu WangGuangming ZhangLin YangJiali GanXijuan Jiang
Published in: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2024)
Calpain, a key member of the Calpain cysteine protease superfamily, performs limited protein hydrolysis in a calcium-dependent manner. Its activity is tightly regulated due to the potential for non-specific cleavage of various intracellular proteins upon aberrant activation. A thorough review of the literature from 2010 to 2023 reveals 121 references discussing cardiovascular and cerebrovascular diseases. Dysregulation of the Calpain system is associated with various pathological phenomena, including lipid metabolism disorders, inflammation, apoptosis, and excitotoxicity. Although recent studies have revealed the significant role of Calpain in cardiovascular and cerebrovascular diseases, the precise mechanisms remain incompletely understood. Exploring the potential of Calpain inhibition as a therapeutic approach for the treatment of cardiovascular and cerebrovascular diseases may emerge as a compelling area of interest for future calpain research.
Keyphrases
  • oxidative stress
  • transcription factor
  • cell death
  • endoplasmic reticulum stress
  • fatty acid
  • single cell
  • small molecule
  • current status
  • amino acid
  • dna binding
  • living cells