Differential effects of oxycodone and venlafaxine on resting state functional connectivity-A randomized placebo-controlled magnetic resonance imaging study.
Tine Maria HansenDina LelicAnne E OlesenAsbjørn Mohr DrewesJens B FrøkjaerPublished in: CNS neuroscience & therapeutics (2018)
Oxycodone and venlafaxine showed differential effects on resting-state functional connectivity as compared to placebo. This supports that the two drugs exert different mechanisms, and that the drugs in combination may exert additive effects and could potentially improve pain therapy.
Keyphrases
- functional connectivity
- resting state
- magnetic resonance imaging
- placebo controlled
- double blind
- chronic pain
- phase iii
- computed tomography
- pain management
- neuropathic pain
- study protocol
- clinical trial
- randomized controlled trial
- stem cells
- phase ii
- squamous cell carcinoma
- open label
- radiation therapy
- cell therapy
- phase ii study