Analysis of archaic human haplotypes suggests that 5hmC acts as an epigenetic guide for NCO recombination.

Bernett LeeSamantha Leeanne CyrillWendy LeeRossella MelchiottiAnand Kumar AndiappanMichael PoidingerOlaf Rotzschke

Published in: BMC biology (2022)

Our results suggest that 5hmC marks may guide the NCO machinery specifically towards functionally relevant regions and, as an intermediate of oxidative demethylation, may open a pathway for environmental influence by specifically targeting recently opened gene loci.

Keyphrases

genome wide
endothelial cells
dna methylation
minimally invasive
gene expression
dna damage
copy number
pluripotent stem cells
cancer therapy
oxidative stress
risk assessment
life cycle