N -Allylation of Azoles with Hydrogen Evolution Enabled by Visible-Light Photocatalysis.
Chang-Ming YouCheng HuangSheng TangPeng XiaoShengchun WangZhen-Hong WeiAiwen LeiHu CaiPublished in: Organic letters (2023)
Direct N -allylation of azoles with hydrogen evolution has been achieved through the synergistic combination of organic photocatalysis and cobalt catalysis. The protocol bypasses stoichiometric oxidants and prefunctionalization of alkenes and produces hydrogen (H 2 ) as the byproduct. This transformation highlights high step- and atom-economy, high efficiency, and broad functional group tolerance for further derivatization, which opens a door for C-N bond formation that is valuable in heterocyclic chemistry.
Keyphrases
- visible light
- high efficiency
- ms ms
- randomized controlled trial
- liquid chromatography tandem mass spectrometry
- gas chromatography mass spectrometry
- high performance liquid chromatography
- molecular dynamics
- simultaneous determination
- liquid chromatography
- cancer therapy
- reduced graphene oxide
- tandem mass spectrometry
- drug discovery
- solid phase extraction
- gas chromatography
- water soluble
- carbon nanotubes
- ultra high performance liquid chromatography
- drug delivery