Genomic Characterization of New Variant of Hydrogen Sulfide (H2S)-Producing Escherichia coli with Multidrug Resistance Properties Carrying the mcr-1 Gene in China †.
Silpak BiswasMohammed ElbediwiGuimin GuMin YuePublished in: Antibiotics (Basel, Switzerland) (2020)
Colistin is considered to be a 'last-resort' antimicrobial for the treatment of multidrug-resistant Gram-negative bacterial infections. Identification of Enterobacteriaceae, carrying the transferable colistin resistance gene mcr-1, has recently provoked a global health concern. This report presents the first detection of a hydrogen sulfide (H2S)-producing Escherichia coli variant isolated from a human in China, with multidrug resistance (MDR) properties, including colistin resistance by the mcr-1 gene, which could have great implications for the treatment of human infections.
Keyphrases
- multidrug resistant
- gram negative
- klebsiella pneumoniae
- escherichia coli
- acinetobacter baumannii
- drug resistant
- endothelial cells
- copy number
- global health
- genome wide
- pseudomonas aeruginosa
- staphylococcus aureus
- biofilm formation
- public health
- cystic fibrosis
- combination therapy
- gene expression
- loop mediated isothermal amplification
- quantum dots
- smoking cessation