Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts.

Diane LefleyFaith HowardFawaz ArshadSteven BradburyHannah BrownClaudia TulottaRachel EyreDenis AlférezJ Mark WilkinsonIngunn HolenRobert B ClarkePenelope D Ottewell

Published in: Breast cancer research : BCR (2019)

Our reliable and clinically relevant humanised mouse models provide significant advancements in modelling of breast cancer bone metastasis.

Keyphrases

bone mineral density
endothelial cells
mouse model
soft tissue
bone loss
bone regeneration
pluripotent stem cells
body composition
breast cancer risk
young adults