Sustained Aurora Kinase B Expression Confers Resistance to PI3K Inhibition in Head and Neck Squamous Cell Carcinoma.

Pooja Anil Shah Vaishnavi Sambandam Anne M Fernandez Hongyun Zhao Tuhina Mazumdar Li Shen Qi Wang Kazi M Ahmed Soma Ghosh Mitchell J Frederick Jing Wang Faye M Johnson

Published in: Cancer research (2022)

Aurora B signaling facilitates resistance to PI3K inhibition in head and neck squamous cell carcinoma, suggesting that combined inhibition of PI3K and Aurora kinase is a rational therapeutic strategy to overcome resistance.

Keyphrases

poor prognosis
binding protein