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Safety and efficacy of long-term sodium channel blocker therapy for early rhythm control: the EAST-AFNET 4 trial.

Andreas RilligLars EckardtKatrin BorofAlan John CammHarry J G M CrijnsAndreas GoetteGuenter BreithardtMarc D LemoineAndreas MetznerLaura RottnerUlrich SchottenEik VettorazziKarl WegscheiderAntonia ZapfHein HeidbuchelStephan WillemsLarissa FabritzRenate B SchnabelChristina MagnussenPaulus F Kirchhof
Published in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2024)
Long-term therapy with flecainide or propafenone appeared to be safe in the EAST-AFNET 4 trial to deliver effective ERC therapy, including in selected patients with stable cardiovascular disease such as coronary artery disease and stable HF. Clinical Trial Registration ISRCTN04708680, NCT01288352, EudraCT2010-021258-20, www.easttrial.org.
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