Effectiveness of BNT162b2 and mRNA-1273 covid-19 vaccines against symptomatic SARS-CoV-2 infection and severe covid-19 outcomes in Ontario, Canada: test negative design study.

Hannah ChungSiyi HeSharifa NasreenMaria E SundaramSarah A BuchanSarah E WilsonBranson ChenAndrew CalzavaraDeshayne B FellPeter C AustinKumanan WilsonKevin L SchwartzKevin A BrownJonathan B GubbayNicole E BastaSalaheddin M MahmudChristiaan H RigholtLawrence W SvensonShannon E MacDonaldNaveed Z JanjuaMina TadrousJeffrey C Kwongnull null

Published in: BMJ (Clinical research ed.) (2021)

Two doses of mRNA covid-19 vaccines were observed to be highly effective against symptomatic infection and severe outcomes. Vaccine effectiveness of one dose was observed to be lower, particularly for older adults shortly after the first dose.

Keyphrases

coronavirus disease
sars cov
respiratory syndrome coronavirus
randomized controlled trial
systematic review
early onset
physical activity
type diabetes
binding protein
skeletal muscle
metabolic syndrome
drug induced
weight loss