HAT-Mediated Electrochemical C(sp 2 )-H Acylation of Quinolines with Alcohols.
Yujie LiaoCong JiangCongcong QiangPing LiuPeipei SunPublished in: Organic letters (2023)
Herein, an electrochemical hydrogen atom transfer (HAT) strategy for C(sp 2 )-H formylation of electron-deficient quinolines and isoquinolines is described. The cheap methanol acts as a formyl source with a catalytic amount of N -hydroxyphthalimide (NHPI) as the hydrogen atom transfer (HAT) catalyst. The advantages of this reaction are transition-metal-catalyst- and chemical-oxidant-free conditions, and the protocol could also be applied to the direct C(sp 2 )-H acetylation or propionylation of quinolines.
Keyphrases
- electron transfer
- ionic liquid
- transition metal
- visible light
- carbon dioxide
- gold nanoparticles
- room temperature
- reduced graphene oxide
- highly efficient
- randomized controlled trial
- molecularly imprinted
- metal organic framework
- label free
- high resolution
- solid phase extraction
- simultaneous determination
- liquid chromatography