Gene Therapy With the N-Terminus of Junctophilin-2 Improves Heart Failure in Mice.
Jinxi WangQian ShiYihui WangLogan W DawsonGrace CiampaWeiyang ZhaoGuangqin ZhangBiyi ChenRobert M WeissChad Eric GrueterDuane D HallLong-Sheng SongPublished in: Circulation research (2022)
Our prevention- and intervention-based approaches here demonstrated that AAV-mediated delivery of JP2NT into the myocardium can attenuate stress-induced transcriptional remodeling and the development of HF when administered either before or after cardiac stress initiation. Our data indicate that JP2NT gene therapy holds great potential as a novel therapeutic for treating hypertrophy and HF.
Keyphrases
- gene therapy
- stress induced
- acute heart failure
- heart failure
- left ventricular
- randomized controlled trial
- electronic health record
- gene expression
- high fat diet induced
- transcription factor
- big data
- cardiac resynchronization therapy
- atrial fibrillation
- type diabetes
- wild type
- insulin resistance
- metabolic syndrome
- skeletal muscle