Clonal Hematopoiesis-Associated Gene Mutations in a Clinical Cohort of 448 Patients With Ovarian Cancer.
Konstantin Weber-LassalleCorinna ErnstAlexander ReussKathrin MöllenhoffKlaus BaumannChristian JackischJan HaukeDimo DietrichJulika BordeTjoung-Won Park-SimonLars C HankerKatharina PrieskeSandra SchmidtNana Weber-LassalleEsther Pohl-RescignoStefan KommossFrederik MarméFlorian HeitzJulia Carolin StinglRita K SchmutzlerPhilipp HarterEric HahnenPublished in: Journal of the National Cancer Institute (2022)
A positive gBRCA1/2 mutation status is not a risk factor to acquire CH-associated gene mutations. OC patients may benefit from monitoring CH-associated gene mutations, especially following carboplatin exposure. Future clinical studies are required to assess whether treatment regimen should be adapted according to individual t-MN risks.