Spastin joins LDs and peroxisomes in the interorganelle contact ballet.

Published in: The Journal of cell biology (2019)

Lipid droplets (LDs) store energy-rich fatty acids (FAs), but to harvest them, LDs donate FAs to peroxisomes for oxidation. In this issue, Chang et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902061) identify M1 Spastin as an LD-peroxisome tether that interacts with ESCRT-III components to facilitate lipid exchange between these two organelles.

Keyphrases

fatty acid
single cell
cell therapy
hydrogen peroxide
binding protein
stem cells
visible light