In vivo CRISPR screen identifies LTN1 as a novel tumor suppressor ubiquitinating insulin-like growth factor 2 mRNA-binding protein 1 in hepatocellular carcinoma.

Dou-Sheng BaiJun CaoChi ZhangJie ZhouBing-Bing SuDao-Yuan TuGuo-Qing JiangSheng-Jie JinYa-Ping XuDou-Sheng Bai

Published in: Hepatology communications (2023)

LTN1 may be a crucial tumor suppressor for determining the prognosis and a possible therapeutic target since it inhibits the proliferation of HCC cells by ubiquitinating IGF2BP1.

Keyphrases

binding protein
genome wide
induced apoptosis
signaling pathway
crispr cas
growth hormone
genome editing
high throughput
dna methylation
gene expression
pi k akt
single cell