Dietary supplementation of a high-temperature-processed green tea extract attenuates cognitive impairment in PS2 and Tg2576 mice.
Juewon KimShinichiro FunayamaNaotaka IzuoTakahiko ShimizuPublished in: Bioscience, biotechnology, and biochemistry (2019)
Green tea intake is generally recognized as an effective supplement that promotes mental clarity and cognitive function. These health benefits of green tea have been attributed mainly to its effective component, epigallocatechin gallate (EGCG). Because various catechin derivatives potently enhance these health benefits, we manipulated the extraction process with a high-temperature intervention. High-temperature-processed green tea extract (HTP-GTE) showed an elevated proportion of gallocatechin gallate (GCG) content. To investigate the preventive effects of HTP-GTE on cognitive decline, we found its neuroprotective effects against amyloid β (Aβ)-induced neurotoxicity in neurons and clarified that GCG significantly inhibited Aβ aggregation in vitro. Moreover, we showed that HTP-GTE intake attenuated several cognitive-decline phenotypes in a model mouse of Alzheimer's disease. These beneficial effects of HTP-GTE against cognitive decline were due to the distinctive composition of the extract and suggest the possibility that HTP-GTE supplementation could attenuate cognitive decline of Alzheimer's disease.
Keyphrases
- cognitive decline
- high temperature
- mild cognitive impairment
- mental health
- oxidative stress
- healthcare
- public health
- cognitive impairment
- randomized controlled trial
- anti inflammatory
- health information
- spinal cord
- high glucose
- type diabetes
- health promotion
- high fat diet induced
- spinal cord injury
- weight gain
- insulin resistance
- risk assessment
- endothelial cells
- body mass index
- wild type