The effect of antidepressants on the severity of COVID-19 in hospitalized patients: A systematic review and meta-analysis.

Hosein Nakhaee Moein ZangiabadianReza BayatiMohammad RahmanianAmir Ghaffari JolfayiSakineh Rakhshanderou

Published in: PloS one (2022)

Most evidence supports that the use of antidepressant medications, mainly Fluvoxamine, may decrease the severity and improve the outcome in hospitalized patients with SARS-CoV-2. Some studies showed contradictory findings regarding the effects of antidepressants on the severity of COVID-19. Further clinical trials should be conducted to clarify the effects of antidepressants on the severity of COVID-19.

Keyphrases

sars cov
coronavirus disease
major depressive disorder
respiratory syndrome coronavirus
clinical trial
bipolar disorder
randomized controlled trial
study protocol
open label
case control