Preventive Effect of Arctium lappa Polysaccharides on Acute Lung Injury through Anti-Inflammatory and Antioxidant Activities.
Nai-Yan LuJiayi WeiXuelei GongXue TangXuan ZhangWen XiangSamuel LiuCherry LuoXun WangPublished in: Nutrients (2023)
The objective of this study was to investigate the preventive effects of polysaccharides extracted from the roots of Arctium lappa (ALP) against acute lung injury (ALI) models induced by lipopolysaccharide (LPS). The polysaccharides were extracted and characterized, and their anti-inflammatory and antioxidant capacities were assessed. The findings demonstrated that ALP could mitigate the infiltration of inflammatory cells and reduce alveolar collapse in LPS-induced ALI in mice. The expression levels of the pro -inflammatory factor TNF-α decreased, while the anti-inflammatory factor IL-10 increased. Furthermore, the administration of ALP improved the activities of lung antioxidant enzymes, including SOD, GSH, and CAT, and lowered MDA levels. These results suggest that ALP exhibits a preventive effect on ALI and has potential as an alternative treatment for lung injury.
Keyphrases
- anti inflammatory
- lps induced
- inflammatory response
- cell cycle arrest
- induced apoptosis
- lipopolysaccharide induced
- water soluble
- poor prognosis
- rheumatoid arthritis
- oxidative stress
- toll like receptor
- breast cancer cells
- adipose tissue
- metabolic syndrome
- cell proliferation
- binding protein
- endoplasmic reticulum stress
- high fat diet induced
- long non coding rna
- insulin resistance
- skeletal muscle
- replacement therapy