Galectin-8 mediates fibrogenesis induced by cyclosporine in human gingival fibroblasts.
Patricio C SmithClaudia MetzAdely de la PeñaClaudia OyanadelPatricio AvilaRodrigo ArancibiaLucas VicuñaClaudio RetamalFrancisca BarakeAlfonso GonzálezAndrea SozaPublished in: Journal of periodontal research (2020)
Taken together, these results reveal for the first time Gal-8 as a fibrogenic stimulus exerted through β1-integrin/FAK pathways in human gingival fibroblasts, which can be triggered by cyclosporine. Further studies should explore the involvement of Gal-8 in human gingival tissues and its role in drug-induced gingival overgrowth.