Galectin-8 mediates fibrogenesis induced by cyclosporine in human gingival fibroblasts.

Patricio Cristian SmithClaudia MetzAdely de la Peña Claudia OyanadelPatricio AvilaRodrigo ArancibiaLucas Vicuña Claudio Retamal Francisca Barake Alfonso González Andrea Soza

Published in: Journal of periodontal research (2020)

Taken together, these results reveal for the first time Gal-8 as a fibrogenic stimulus exerted through β1-integrin/FAK pathways in human gingival fibroblasts, which can be triggered by cyclosporine. Further studies should explore the involvement of Gal-8 in human gingival tissues and its role in drug-induced gingival overgrowth.

Keyphrases

endothelial cells
drug induced
induced pluripotent stem cells
pluripotent stem cells
gene expression
cell migration
adverse drug