Galectin-8 mediates fibrogenesis induced by cyclosporine in human gingival fibroblasts.

Patricio C SmithClaudia MetzAdely de la Peña Claudia OyanadelPatricio AvilaRodrigo ArancibiaLucas Vicuña Claudio Retamal Francisca Barake Alfonso González Andrea Soza

Published in: Journal of periodontal research (2020)

Taken together, these results reveal for the first time Gal-8 as a fibrogenic stimulus exerted through β1-integrin/FAK pathways in human gingival fibroblasts, which can be triggered by cyclosporine. Further studies should explore the involvement of Gal-8 in human gingival tissues and its role in drug-induced gingival overgrowth.

Keyphrases

endothelial cells
drug induced
induced pluripotent stem cells
pluripotent stem cells
gene expression
cell migration
adverse drug