All-trans retinoic acid (ATRA)-induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL).
Nina OrfaliTracey R O'DonovanMary R CahillDalyia BenjaminDavid M NanusSharon L McKennaLorraine J GudasNigel P MonganPublished in: European journal of haematology (2020)
We show for the first time that TFEB plays an important role in ATRA-induced autophagy during myeloid differentiation and that autophagy induction potentiates leukemic cell differentiation (Note: this study includes data obtained from NCT00195156, https://clinicaltrials.gov/show/NCT00195156).
Keyphrases
- acute myeloid leukemia
- bone marrow
- diabetic rats
- high glucose
- drug induced
- cell death
- oxidative stress
- signaling pathway
- dendritic cells
- endoplasmic reticulum stress
- liver failure
- poor prognosis
- intensive care unit
- immune response
- endothelial cells
- machine learning
- respiratory failure
- long non coding rna
- binding protein