Reduced expression of apolipoprotein E and immunoglobulin heavy constant gamma 1 proteins in Fuchs endothelial corneal dystrophy.

Abraham KuotMaurizio RonciRichard MillsSonja KlebeGrant SnibsonSteven WiffenRaymond LohMark CorbettTiger ZhouTim ChatawayKathryn P BurdonJamie E CraigAndrea UrbaniShiwani Sharma

Published in: Clinical & experimental ophthalmology (2019)

This is the first study to report comparative proteomics of Descemet's membrane tissue, and implicates dysregulation of APOE and IGHG1 proteins in the pathogenesis of Fuchs endothelial corneal dystrophy.

Keyphrases

endothelial cells
early onset
optical coherence tomography
poor prognosis
mass spectrometry
wound healing
cognitive decline
binding protein
metabolic syndrome
skeletal muscle
label free
insulin resistance