CD4 T lymphocyte autophagy is upregulated in the salivary glands of primary Sjögren's syndrome patients and correlates with focus score and disease activity.
Cristiano AlessandriFrancesco CicciaRoberta PrioriElisa AstorriGiuliana GugginoRiccardo AlessandroAroldo RizzoFabrizio ContiAntonina MinnitiCristiana BarbatiMarta VomeroMonica PendolinoAnnacarla FinucciElena OrtonaTania ColasantiMarina PierdominiciWalter MalorniGiovanni TrioloGuido ValesiniPublished in: Arthritis research & therapy (2017)
These findings suggest that CD4+ T lymphocyte autophagy could play a key role in pSS pathogenesis. Additionally, our data highlight the potential exploitation of T cell autophagy as a biomarker of disease activity and provide new ground to verify the therapeutic implications of autophagy as an innovative drug target in pSS.
Keyphrases
- disease activity
- rheumatoid arthritis
- systemic lupus erythematosus
- rheumatoid arthritis patients
- cell death
- endoplasmic reticulum stress
- ankylosing spondylitis
- signaling pathway
- oxidative stress
- juvenile idiopathic arthritis
- end stage renal disease
- chronic kidney disease
- ejection fraction
- machine learning
- climate change
- big data
- nk cells
- data analysis
- deep learning