Advances of Protein Palmitoylation in Tumor Cell Deaths.
Xiangyi LinYuxuan ShiYuxin ZhanYuying XingYu LiZhiqing ZhouGuoan ChenPublished in: Cancers (2023)
In this comprehensive survey, we delve into the multifaceted role of palmitoylation across various cell death modalities in the oncological context, from its intricate correlations with tumorigenesis, steered by the Asp-His-His-Cys tetrapeptide motif (DHHC) family, to the counter-process of depalmitoylation mediated by enzymes like Palmitoyl protein thioesterase-1 (PPT1). Innovations in detection methodologies have paralleled our growing understanding, transitioning from rudimentary techniques to sophisticated modern methods. Central to our discourse are agents like Ezurpimtrostat (GNS561) and dimeric chloroquine (DC661), promising heralds in palmitoylation-targeted cancer therapy. Collectively, this review accentuates palmitoylation's transformative potential in oncology, foreshadowing groundbreaking therapeutic strategies and deepening our molecular comprehension of cancer dynamics.
Keyphrases
- cancer therapy
- cell death
- drug delivery
- papillary thyroid
- protein protein
- molecular dynamics
- amino acid
- single cell
- palliative care
- binding protein
- molecular dynamics simulations
- dendritic cells
- cell therapy
- cross sectional
- prostate cancer
- rectal cancer
- squamous cell
- stem cells
- squamous cell carcinoma
- loop mediated isothermal amplification
- risk assessment
- signaling pathway
- sensitive detection