Effect of Platelet-Activating Factor on Barrier Function of ARPE-19 Cells.
Fan ZhangLei LiuHan ZhangZhe-Li LiuPublished in: Drug design, development and therapy (2020)
The barrier functions of ARPE-19 cells were altered by PAF, and these effects were partly mediated by an upregulation of VEGF expression in these cells. Our results contribute to the growing body of evidence supporting the role of PAF in choroidal neovascularization. Our findings suggest that PAF is a novel target in the development of therapies for increased permeability of the RPE monolayer.