Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function.

Arielle HallTatiana FontelongaAlec WrightKatlynn Bugda GwiltJeffrey WidrickAlessandra PasutFrancesco VillaCynthia K MirantiDevin GibbsEvan JiangHui MengMichael W LawlorEmanuela Gussoni

Published in: Skeletal muscle (2020)

Basal CD82 expression is important to dystrophic muscle, as its loss leads to significantly weakened myofibers and impaired muscle function, accompanied by decreased satellite cell activity that is unable to protect and repair myofiber damage.

Keyphrases

skeletal muscle
stem cells
poor prognosis
oxidative stress
cell therapy
nk cells