ARID5B-mediated LINC01128 epigenetically activated pyroptosis and apoptosis by promoting the formation of the BTF3/STAT3 complex in β2GPI/anti-β2GPI-treated monocytes.
Yuan TanJiao QiaoShuo YangQingchen WangHongchao LiuQi LiuWeimin FengBoxin YangZhongxin LiLiyan CuiPublished in: Clinical and translational medicine (2024)
The H3K4me3 mark and chromatin accessibility at the ARID5B promoter are increased in vitro model mimicked APS. ARID5B-mediated LINC01128 induces pyroptosis and apoptosis via p-STAT3 by binding to BTF3. ARID5B is high- expressed in patients with primary APS and positively correlated with LINC01128 expression. OICR-9429 treatment mitigates pyroptosis and related inflammation in vivo and in vitro models mimicked APS.
Keyphrases
- cell proliferation
- long noncoding rna
- long non coding rna
- oxidative stress
- poor prognosis
- nlrp inflammasome
- endoplasmic reticulum stress
- cell cycle arrest
- gene expression
- transcription factor
- cell death
- dna damage
- pi k akt
- radiation therapy
- binding protein
- peripheral blood
- combination therapy
- replacement therapy
- smoking cessation
- newly diagnosed