Anti-phospholipid antibodies are elevated and functionally active in chronic rhinosinusitis with nasal polyps.
Jacob G EideJeffanie WuWhitney W StevensJunqin BaiSongwang HouJulia H HuangJacob RosenbergPaul UtzStephanie Shintani-SmithDavid B ConleyKevin C WelchRobert C KernKathryn E HulseAnju T PetersLeslie C GrammerMing ZhaoPaul LindholmRobert P SchleimerBruce K TanPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2022)
APA IgG antibodies are increased in NP and correlate with autoreactive tissue antibodies. NP antibodies have in vitro anti-coagulant activity similar to those observed in anti-phospholipid syndrome, suggesting that they may have pro-coagulant effects in polyp tissue.