Natural killer-cell immunoglobulin-like receptors trigger differences in immune response to SARS-CoV-2 infection.
Roberto LitteraLuchino ChessaSilvia DeiddaGoffredo AngioniMarcello CampagnaSara LaiMaurizio MelisSelene CipriDavide FirinuSimonetta SantusAlberto LaiRita PorcellaStefania RassuFederico MeloniDaniele SchirruWilliam CordedduMarta Anna KowalikPaola RagatzuMonica VaccaFederica CannasFrancesco AlbaMauro Giovanni CartaStefano Del GiaccoAngelo RestivoSimona DeiddaAntonella PalimoddePaola CongeraRoberto PerraGermano OrrùFrancesco PesMartina LoiClaudia MurruEnrico UrruSimona OnaliFerdinando CogheSabrina GiglioAndrea PerraPublished in: PloS one (2021)
The KIR2DS2/HLA C1 functional unit resulted to have a strong protective effect against the adverse outcomes of COVID-19. Combined to other well known factors such as advanced age, male sex and concomitant autoimmune diseases, this marker could prove to be highly informative of the disease course and thus enable the timely intervention needed to reduce the mortality associated with the severe forms of SARS-CoV-2 infection. However, larger studies in other populations as well as experimental functional studies will be needed to confirm our findings and further pursue the effect of KIR receptors on NK cell immune-mediated response to SARS-Cov-2 infection.