Relation Between Reactive Oxygen Species Production and Transient Receptor Potential Vanilloid1 Expression in Human Skin During Aging.
Gaia FaveroMarzia GianòCaterina FrancoDaniela PintoCornelis J F van NoordenFabio RinaldiRita RezzaniPublished in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (2024)
Skin sensitivity and impaired epidermal barrier function are associated with aging and are at least partly due to increased production of reactive oxygen species (ROS). Transient receptor potential vanilloid1 (TRPV1) is expressed in keratinocytes, fibroblasts, mast cells, and endothelial cells in skin. We investigated in skin biopsies of adult and elderly donors whether TRPV1 expression is involved in the skin aging process. We found that aging skin showed a strongly reduced epidermal thickness, strongly increased oxidative stress, protease expression, and mast cell degranulation and strongly increased TRPV1 expression both in epidermis and dermis. Based on our findings, the aging-related changes observed in the epidermis of the skin level are associated with increased ROS production, and hypothesized alterations in TRPV1 expression are mechanistically linked to this process.
Keyphrases
- poor prognosis
- reactive oxygen species
- wound healing
- soft tissue
- oxidative stress
- binding protein
- endothelial cells
- cell death
- long non coding rna
- mass spectrometry
- optical coherence tomography
- high resolution
- cerebral ischemia
- subarachnoid hemorrhage
- single molecule
- diabetic rats
- endoplasmic reticulum stress
- vascular endothelial growth factor