Discovery of alantolactone as a natural NLRP3 inhibitor to alleviate NLRP3-driven inflammatory diseases in mice.

Weifeng LiHaowen XuJingjing ShaoJiahao ChenYimin LinZhiwei ZhengYi WangWu LuoGuang Liang

Published in: British journal of pharmacology (2023)

In summary, we identified ALA as a natural inhibitor of NLRP3 inflammasome by directly targeting NLRP3 NACHT domain. ALA shows great potential in the treatment of NLRP3-driven diseases and the development of novel NLRP3 inhibitors.

Keyphrases

nlrp inflammasome
small molecule
oxidative stress
drug delivery
cancer therapy
climate change
human health
single cell
smoking cessation