Gene profiling of Toll-like receptor signalling pathways in neutrophils of patients with acute-on-chronic liver failure.
Yi ZhangWei WuYijie WangLingjia TongMeng HongQi XiaZhi ChenPublished in: Journal of translational medicine (2021)
TLR signalling pathway genes were differentially regulated in neutrophils between cirrhosis and ACLF. In ACLF patients, defective expression of TLR3 and IFN, along with enhanced CD14 and IL10 expression, was characterized by transcriptional alterations of neutrophils.
Keyphrases
- toll like receptor
- inflammatory response
- immune response
- liver failure
- nuclear factor
- poor prognosis
- end stage renal disease
- genome wide
- transcription factor
- newly diagnosed
- ejection fraction
- hepatitis b virus
- chronic kidney disease
- gene expression
- binding protein
- single cell
- peritoneal dialysis
- genome wide identification
- prognostic factors
- heat shock
- long non coding rna
- bioinformatics analysis
- genome wide analysis