Mitochondrial Haplogroups and Weight Gain After Initiating ART in Patients with HIV.
Juan BerenguerInmaculada JarrínJosé M BellónCristina DíezMaría A Jiménez-SousaJuan C LópezAdriana Pinto-MartínezSantiago MorenoMaría L MontesJosé A IribarrenEva OrvizJoaquín PortillaFrancesc VillarroyaPere DomingoSalvador Resinonull nullPublished in: The Journal of infectious diseases (2024)
We studied the association of mitochondrial DNA (mtDNA) haplogroups with weight and body mass index (BMI) gain at 96 weeks in 1,019 treatment-naïve persons with HIV (PWH) who initiated first-line antiretroviral therapy (ART) since 2014. The mean increase in weight and BMI over the study period was 2.90 Kg and 0.98 Kg/m2, respectively. We found a significant adjusted association between the major UK mtDNA haplogroup and lower weight and BMI increase at 96 weeks after ART initiation. Our findings reveal a potential role for mitochondrial genetics in the complex phenomenon of weight gain after initial ART in PWH.
Keyphrases
- weight gain
- antiretroviral therapy
- mitochondrial dna
- body mass index
- hiv infected
- copy number
- hiv positive
- human immunodeficiency virus
- birth weight
- hiv aids
- hiv infected patients
- oxidative stress
- genome wide
- weight loss
- physical activity
- gestational age
- gene expression
- single cell
- dna methylation
- cross sectional
- replacement therapy
- combination therapy
- south africa
- body weight