Life-Threatening Enterovirus 71 Encephalitis in Unrelated Children with Autosomal Dominant TLR3 Deficiency.

Chen-Yen KuoCheng-Lung KuHye-Kyung LimShao-Hsuan HsiaJainn-Jim LinChia-Chi LoJing-Ya DingRei-Lin KuoJean-Laurent CasanovaShen-Ying ZhangLuan-Yin ChangTzou-Yien Lin

Published in: Journal of clinical immunology (2022)

Autosomal dominant TLR3 deficiency may underlie severe EV71 infection with encephalitis. Human TLR3 immunity is essential to protect the central nervous system against HSV-1 and EV71. Children with severe EV71 infections, such as encephalitis in particular, should be tested for inborn errors of TLR3 immunity.

Keyphrases

toll like receptor
inflammatory response
immune response
young adults
nuclear factor
endothelial cells
early onset
patient safety
drug induced
pluripotent stem cells