Life-Threatening Enterovirus 71 Encephalitis in Unrelated Children with Autosomal Dominant TLR3 Deficiency.
Chen-Yen KuoCheng-Lung KuHye-Kyung LimShao-Hsuan HsiaJainn-Jim LinChia-Chi LoJing-Ya DingRei-Lin KuoJean-Laurent CasanovaShen-Ying ZhangLuan-Yin ChangTzou-Yien LinPublished in: Journal of clinical immunology (2022)
Autosomal dominant TLR3 deficiency may underlie severe EV71 infection with encephalitis. Human TLR3 immunity is essential to protect the central nervous system against HSV-1 and EV71. Children with severe EV71 infections, such as encephalitis in particular, should be tested for inborn errors of TLR3 immunity.