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Life-Threatening Enterovirus 71 Encephalitis in Unrelated Children with Autosomal Dominant TLR3 Deficiency.

Chen-Yen KuoCheng-Lung KuHye-Kyung LimShao-Hsuan HsiaJainn-Jim LinChia-Chi LoJing-Ya DingRei-Lin KuoJean-Laurent CasanovaShen-Ying ZhangLuan-Yin ChangTzou-Yien Lin
Published in: Journal of clinical immunology (2022)
Autosomal dominant TLR3 deficiency may underlie severe EV71 infection with encephalitis. Human TLR3 immunity is essential to protect the central nervous system against HSV-1 and EV71. Children with severe EV71 infections, such as encephalitis in particular, should be tested for inborn errors of TLR3 immunity.
Keyphrases
  • toll like receptor
  • inflammatory response
  • immune response
  • young adults
  • nuclear factor
  • endothelial cells
  • early onset
  • patient safety
  • drug induced
  • pluripotent stem cells