Novel chromobox 2 inhibitory peptide decreases tumor progression.
Lindsay W BrubakerDonald S BackosVu T NguyenPhilip ReiganTomomi M YamamotoElizabeth R WoodruffRitsuko IwanagaMichael F WempeVijay KumarChristianne PersenaireZachary L WatsonBenjamin G BitlerPublished in: Expert opinion on therapeutic targets (2023)
The CBX2 blocking peptide significantly inhibited both 2D and 3D growth of ovarian cancer cells, downregulated a CBX2 target gene, and blunted tumor growth in vivo.