Hybrid-control arm construction using historical trial data for an early-phase, randomized controlled trial in metastatic colorectal cancer.
Chen LiAna FerroShivani K MhatreDanny LuMarcus LawranceXiao LiShi LiSimon AllenJayesh DesaiMarwan FakihMichael CecchiniKatrina S PedersenTae You KimIrmarie Reyes-RiveraNeil H SegalChristelle LenainPublished in: Communications medicine (2022)
Hybrid control provides comparable treatment-effect estimates with generally improved precision, and thus can be of value to inform early-phase clinical development in metastatic colorectal cancer.